HTA Core Model® Online

Adaptation toolkit

This project was funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project number 05/52/01) and was published in full in Health Technology Assessment 2009; Vol.13: No.59

The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HTA programme, NIHR, NHS or the Department of Health.

The Adaptation Toolkit was developed as part of Workpackage 5 of the EUnetHTA 2006-2008 project. This was led by the NIHR Evaluation, Trials and Studies Coordinating Centre (formerly NCCHTA, based at the University of Southampton, UK). This tool aims to enable users to help HTA agencies to adapt HTA reports from other countries, regions or settings for their own use. The purpose of adaptation is to enable an HTA agency in one setting to make use of an HTA report produced elsewhere, thus saving time and money.

Speedy sifting

You can access the speedy sifting within the HTA Core Model Online from the left-hand menu once you have first selected a collection for viewing.

General toolkit resources

The table below lists general toolkit resources and hyperlinks to those resources. These resources provide information on adaptation issues, transferability questions and previous related EU funded projects. These resources can be consulted if further information and guidance is required in these areas.

General adaptation issues
WHO review of the literature on applicability, transferability, and adaptation of guidelines.	http://www.health-policy-systems.com/content/4/1/25 link last checked: 10/2019
Paper describing the structures and working methods of guideline programs.	http://intqhc.oxfordjournals.org/cgi/content/full/15/1/31 link last checked: 10/2019
AGREE (Appraisal of Guidelines, Research and Evaluation in Europe) project paper on the development and validation of an international instrument for assessing the quality of the process and reporting of clinical practice guideline development.
Report from the Conference on Guideline Standardization to define a standard for guideline reporting.	http://www.annals.org/cgi/reprint/139/6/493.pdf link last checked: 10/2019
Paper reviewing the literature on adaptation of guidelines and to propose a systematic approach for adaptation of guidelines.	http://intqhc.oxfordjournals.org/cgi/content/abstract/18/3/167 link last checked: 10/2019
A series of reviews of methods that are used in the development of guidelines.	http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17116254 link last checked: 10/2019
Questions relating to how generalisability can be tackled in systematic reviews	http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862005000600020&lng=en&nrm=iso&tlng=en link last checked: 10/2019
Clinical guidelines are only as good as the evidence and judgments they are based on. The GRADE (Grades of Recommendation Assessment, Development and Evaluation) approach aims to make it easier for users to assess the judgments behind recommendations.	http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15205295 link last checked: 10/2019
Previous EU funded projects
ECHTA/ECAHI Report – “European collaboration for health technology assessment: developing an assessment network” and HTA Europe Report – “Health Technology Assessment in the European Union”
EUR-ASSESS Project Subgroup report on Methodology. Methodological guidance for the conduct of health technology assessment	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9194352&dopt=Citation link last checked: 10/2019
Working Group 4 Report to develop and disseminate best practice in undertaking and reporting assessments, and to identify needs for methodological development.	http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=106849 link last checked: 10/2019
Transferability issues
Checklist for identifying guidelines requiring adaptation. It contains questions around factors which influence the applicability or transferability of guidelines across different settings. Questions relevant for the safety, effectiveness and cost-effectiveness domains of the toolkit.	http://www.health-policy-systems.com/content/4/1/25/table/T1 link last checked: 10/2019
General HTA resources
NICHR (National Information Center on Health Services Research and Health Care Technology) HTA 101: Introduction to HTA	https://www.nlm.nih.gov/nichsr/htawebinars/HTA_101_Transcript.html link last checked: 10/2019